Follows the tale of a young woman’s sexual awakening and subsequent journey around the world in pursuit of her ideal lover. Encounters include an Arabian sheik and a Spanish bullfighter. Her friend and butler accompany her and help to arrange her couplings.

Graham Young is a teenage misfit living in suburban London in the 1960s. He hates his stepmother but loves chemistry, and the two impulses unite in a wicked plot to slowly poison her. After she dies, he's found guilty and sent to a psychiatric hospital, where an idealistic doctor thinks he can be cured.

Helen, a London ad executive, is fired from her job and rushes out to catch a train, but, as she runs down, her life suddenly splits off. In one version she catches the train; in the second, she misses it. Her whole life changes in that one second, and the rest of the film depicts what happens in each scenario.

Over the course of five social occasions, a committed bachelor must consider the notion that he may have discovered love.

The London branch of Whitney Paine, a major American investment bank, is in the midst of a crisis; after the loss of $100 million, one of their leading traders, Tony Eisner commits suicide by putting a slug through his head while seated at his place in the board room. Despite the high stakes, many of the firm's staff are eager to step into Tony's now-vacated shoes and get credit for saving the company. Daniel Pascoe, the leading trader at the firm, is convinced that he's first in line for the assignment, but the firm imports a new trader from America, Anna Schuman. Daniel is enraged and makes a point of trying to dig up as much dirt on Anna as he can, but things are going to take another turn.

On the death of her mother, a young woman in northern England learns that her father is actually her step-father. She embarks on a search for her birth father, finds him running a jazz club in London, and learns a lot of happy and sad things about her family that she didn't know before. The title of the film is the classic jazz piece, "Misterioso," by Thelonious Monk, which features prominently in it.