Set in 1958, the coming of age story follows four lower middle-class Brooklyn teenagers known as The Lords of Flatbush. The Lords chase girls, steal cars, shoot pool, get into street fights, and hang out at a local malt shop.

Dr. Bock, the chief of medicine at a Manhattan hospital, is suicidal after the collapse of his personal life. When an intern is found dead in a hospital bed, it appears to Bock to be a case of unforgivable malpractice. Hours later, another doctor, who happens to be responsible for another case of malpractice, is found dead. Despondent, Bock finds himself drawn to Barbara, the daughter of a comatose missionary.

Three Italian-American brothers, living in the slums of 1940's New York City, try to help each other with one's wrestling career using one brother's promotional skills and another brother's con-artist tactics to thwart a sleazy manager.

A stark portrayal of life among a group of heroin addicts who hang out in Needle Park in New York City. Played against this setting is a low-key love story between Bobby, a young addict and small-time hustler, and Helen, a homeless girl who finds in her relationship with Bobby the stability she craves.