Though Rachel is a successful attorney and a loyal, generous friend, she is still single. After one drink too many at her 30th-birthday celebration, Rachel unexpectedly falls into bed with her longtime crush, Dex -- who happens to be engaged to her best friend, Darcy. Ramifications of the liaison threaten to destroy the women's lifelong friendship, while Ethan, Rachel's confidant, harbors a potentially explosive secret of his own.

The film follows a backpack on a journey around the world, intersecting the lives of dozens of fascinating characters along the way. The story progresses, we learn details about the mysterious man to whom the bag belongs.

In 1999, a woman's life is forever changed after she survives a car crash with two bank robbers, who enlist her help to take the money to a drop in Paris. On the way, she runs into another fugitive from the law — an American doctor on the run from the CIA. They want to confiscate his father's invention – a device which allows anyone to record their dreams and visions.