Inspired by real life events, Madame Luna tells the story of an Eritrean refugee who is washed ashore in Libya and survives to become one of the most notorious human smugglers, with deep ties to the Italian Mafia. Now trapped in Italy and forced to experience the brutalising reality endured by the people she has exploited in the past, Madame Luna must try to find a way out before she is recognized and brought to justice. In the process she forms a powerful bond with a younger version of herself.

Inside a warehouse in Palermo, a group of people smashes a man’s arm to pieces with a wheelie bag packed with weights. This is the method used by an amateur criminal organization that fractures the limbs of its willing victims before staging fake accidents and raking in the insurance payouts. Vincenzo recruits the individuals from among the down-and-outs that haunt the city streets, where Luisa is a habitué, since she gets her crack there. Vincenzo’s problems suddenly get worse, though, after a series of mistakes shut him out of the gang, and Luisa is now his only chance: he convinces her to have her bones broken.

Palermo, Sicily, 1980. Mafia member Tommaso Buscetta decides to move to Brazil with his family fleeing the constant war between the different clans of the criminal organization. But when, after living several misfortunes, he is forced to return to Italy, he makes a bold decision that will change his life and the destiny of Cosa Nostra forever.