Nat drives on the interstate with his two young daughters in the back seats, when a car drives by and an unknown guy shoots one of his daughters dead for no reason. Nat's life is shattered. He becomes obsessed with finding the killers, assaults two men, kills one, goes to jail, is left by his wife, grows old estranged from his other daughter. We see the action first through Nat's eyes, then via Brautigan, the cop in charge of the investigation, and finally from the perspective of the remaining daughter Margo. The deconstructed narrative echoes the chaos within Nat and emphasizes the fact that the characters are out of tune with one another, which is the meaning of the original title.

Just before the massacre of Donkergat during the Anglo-Boer war, Commandant Piet van Kloten buries a fortune in Kruger Rands in the area of the battlefield. So that he would remember where he buried the treasure he draws a rough map. He tears it in half and gives one half to his servant Plaatjies, extracting a promise that he will not let it fall into the wrong hands should he survive the battle.

Denny Montana never looks at Claire. She has been working for him for four years and fallen in love at a distance. When Denny's brother Regan returns to oversee the sale of the family vineyard, Claire and Reganen makes pact. To make Denny jealous and lure him away from his girlfriend's bad influence. But what Claire and Regan did not take into account was how difficult it can be to control their own emotions.

Samuel Browne is a tracker in Alaska. When his sister meets a grisly death in San Francisco, he goes there to hunt her killer. As more murders occur, police investigator Buckley Clarke reluctantly joins forces with Sam. The brass are convinced this is a serial killer choosing victims at random, but Sam and Buckley discover a pattern involving health personnel who work in neonatal intensive care. Doctors aren't supposed to play god, but someone's decision years before has driven a killer over the brink. Can they find him?

First Officer John Carter is aboard a cruise ship hijacked by terrorists who plan to steal gold bullion from a U.S. Treasury ship, using a nuclear bomb as leverage