Almería, Tabernas desert, Spain, 2002. Texas Hollywood is a dilapidated and dusty town where Western movies have not been shot for decades. Julián Torralba and his partners, veteran film stuntmen, survive there, recreating pathetic action scenes for the pleasure of the few foreign tourists who visit the isolated region.

A peaceful gas-station employee is pursued by a pair of civil guardians. The story is told by a bizarre conception of time and space, unleashing a frenetically humorous and bizarre odyssey.

A popular and beautiful politician plans to expose the evil-doings of a multinational corporation. Hoping to silence her, the corporation's top executives decide to hire the most incompetent detective they can find to act as her bodyguard.

In the Headquarters of the T.I.A. (Terminal Intelligence Agency), someone has stolen Professor Bacterio's most dangerous invention, the D.O.T. (Demoralizer of Troops), an artifact that ends up in the hands of a very short, wacky dictator who is ready to use it for criminal purposes. The T.I.A Chief, though, is firm in his resolve: if he wants to get the D.O.T. back, he must NOT count on his agents Mortadelo & Filemon. But when the crime fighting duo discover that the T.I.A. has engaged a cocky and slimy detective from outside the agency, they decide to act at their own risk, even if that risk involves all of Humanity.

Santos, a failed comic book artist, lives in a parallel universe where he's a superhero who has to save the world.