Suddenly appearing in Florence, an evil seductress causes Cesare, the city's ruler, and his son to both fall madly in love with her. The son, killing his father before an order to torture the woman can be carried out, then turns the city's churches into dens of sexual debauchery. Acts of evil and corruption continue unabated until the arrival of Death, who brings with her a horrible plague which she is about to loose upon the city.

The film tells the story of Ivan Mazeppa, a Ukrainian page at the Polish court who has an affair with the young wife of a much older count. Outraged when he learns of the incident, the nobleman has Mazeppa tied naked to a wild horse which is then released into the wilderness. The bulk of the poem describes the long hazardous journey during which Mazeppa almost dies twice but ultimately survives and returns to his native Ukraine.