One year after the events of "Kickboxer: Vengeance", Kurt Sloan has vowed never to return to Thailand. However, while gearing up for a MMA title shot, he finds himself sedated and forced back into Thailand, this time in prison. He is there because the ones responsible want him to face a 6'8" 400 lbs. beast named Mongkut and in return for the fight, Kurt will get two million dollars and his freedom back. Kurt at first refuses, in which a bounty is placed on his head as a way to force him to face Mongkut. Kurt soon learns he will have no other choice and will undergo his most rigorous training yet under some unexpected mentors in order to face Mongkut in hopes to regain his freedom.

Ah Fat, a lonely man arrives in a strange country, escaping from his past and seeking salvation. Living in a constant state of psychological turmoil, redemption was never quite in reach. Making friends with Miumiu, a coworker who is a gogo girl and a male gigolo Pumpkin turns Ah Fat's life around; he finds a strange, unique sort of happiness in friendship that had evaded him for a long time. Then comes a turn of events that changes everything; Ah Fat will have to choose between saving his friends by killing the evil shop owner, and standing idly by. This is the final straw; Ah Fat is pushed to the brink, all hell breaks loose...