The two brothers Bobby-John-Joe and Billy-Bob-Earl St. John live with their alcoholic mother on a farm in the Wild West. Suddenly, their missing father Jerry-Lee-Larry reappears. He disappeared twenty years ago with his daughter Jill-Sarah-Mae-Jennifer. He claims that Jill was abducted. But as it turns out, Pa is a wanted crook. Ma St. John sends her sons to town to have him picked up by the sheriff.

Lukas Maler is a butcher. Albeit more out of necessity than out of passion: As the “Karajan with the scalpel”, his vocation was always forensic medicine. When he accidently destroyed all evidence against the “24-hour-killer”, his career as a coroner was done for. And not far from it was his marriage with his great love Diana, whom he could not offer anything anymore as a broken man. But Lukas gets a second chance when once again a serial killer terrifies the city because the murders resemble those of the “24-hour-killer”. Diana – who has ascended to head of the forensic institute in the meantime – knows that only the best one can solve the case. But he is not available. And so, she gets the second-best one: the most over-qualified butcher in town…

Sebastian, the creative head of an advertising agency, has just finished a long night and wants to delight his lover with an intimate e-mail. So takes a photo of his best 'piece'. But with a wrong mouse-click posts it to his whole company, with no way to stop it! So do his colleagues also believe that size matters?