Frontier scout Daniel Boone is sent out to locate the only two survivors of General Braddock's men that are believed two have lived through an Indian massacre.

Late in the Civil War, three Confederate soldiers escape from a Union prison camp in Missouri. They soon fall into the hands of pro-Confederate raiders, who force them to act as "outriders" (escorts) for a civilian wagon train that will be secretly transporting Union gold from Santa Fe, New Mexico, to St. Louis, Missouri. The three men are to lead the wagons into a raider trap in Missouri, but one of them starts to have misgivings....

Impoverished by the Civil War and eager to replenish his fortune in the West, Colonel Halliday, his wife, and his daughter, Beth, proceed toward Salina, Kansas by wagon train, at the persuasion of Tom Kirby, a government scout and Beth's fiancé. Although Bill Hickok, Tom's friend, and a company of cavalry are in charge, Pawnee Killer, chief of the Sioux, attacks the wagon train, and Halliday and his wife are killed. Bill rides to Salina for help and to deliver the news to Buffalo Bill Cody. Beth, now hostile to Kirby, joins the household of Lige Morris, a trader in Salina, and, at the suggestion of Bill, Kirby joins General Custer's scouting expedition.