The Addams Family goes on a search for their relatives. Gomez and Morticia are horrified to discover that Grandpa and Grandma Addams have a disease that is slowly turning them "normal". The only chance they have of a cure is to find a family member hoping that they know a home remedy.

Don is a real estate salesman who volunteers at a "hotline for hope". Ann, who works in a photo store, has been told by her boyfriend that he doesn't love her anymore and wants to break up. To try to win him back, she records a videotape where she tells him things she never told him. When Don and Ann cross paths, their lives change fundamentally.