Amid a rapidly changing cityscape, the lives of a disparate group of swindlers, hustlers, gangsters, and expats collide, with a naive French teenager and a sensitive young local who tries to protect her caught dangerously in the middle.

Framed for crimes against the country, the G.I. Joe team is terminated by Presidential order. This forces the G.I. Joes into not only fighting their mortal enemy Cobra; they are forced to contend with threats from within the government that jeopardize their very existence.

The greedy Braylon owns the Just Rite Sugar Company and has hired the unethical scientist Sergei to conduct an experiment to make an addictive sugar stronger than heroin or nicotine to increase his sales. Sergei uses invisible people as test subjects, like beggars, addicted junkies and illegals, in the clandestine Shadow Rock Mill. When Braylon's men mistakenly kidnap Ryan, who is the brother of his secretary Erin and son of his security chief Griff, and Hannah, the youngster becomes an important non-contaminated subject. However, Erin receives some mysterious e-mails from the unknown Cinderella with a picture of Ryan and a hint that he might be in Shadow Rock and together with her father, they decide to seek out Ryan.

New Orleans has the No. 1 per capita murder rating in the nation. A decade earlier, the city was dubbed the "Murder Capital of the Country". Drugs and violence controlled the streets, taking a toll on the city's law enforcement, neighborhoods, and its people. "Death Toll" illustrates this dark chapter in the city's history.