When the Justice League goes missing and villains overrun Metropolis, there's only one team that can solve this mystery: Scooby-Doo and the gang! But wait, there's a new dog in town – Krypto – Superman's Superdog with Super Powers. Mystery Inc. will need all the help it can get when phantoms menace the Justice League's headquarters.

Everyone's favorite yellow canary unexpectedly becomes next in line for the crown when the queen of an island paradise disappears. His Little Highness’ entourage includes motorbike daredevil Granny and sly Sylvester, whose allegiance is tested when he uncovers a sinister plot to eliminate Tweety for good.

A panicked young woman and her two best friends fly to Mexico to delete a ranting email she sent to her new boyfriend. On arrival, they run into her former beau, who soon gets caught up in their frantic scheme.