The accidental mix-up of four identical plaid overnight bags leads to a series of increasingly wild and wacky situations.

A town—where everyone seems to be named Johnson—stands in the way of the railroad. In order to grab their land, robber baron Hedley Lamarr sends his henchmen to make life in the town unbearable. After the sheriff is killed, the town demands a new sheriff from the Governor, so Hedley convinces him to send the town the first black sheriff in the west.

As the result of a head injury, brilliant computer scientist Harry Benson begins to experience violent seizures. In an attempt to control the seizures, Benson undergoes a new surgical procedure in which a microcomputer is inserted into his brain. The procedure is not entirely successful.

The madcap life of eccentric Mame Dennis and her bohemian, intellectual arty clique is disrupted when her deceased brother's 10-year-old son Patrick is entrusted to her care. Rather than bow to convention, Mame introduces the boy to her free-wheeling lifestyle, instilling in him her favorite credo, "Life is a banquet, and most poor sons of bitches are starving to death."

Police Lieutenant Lon McQ investigates the killing of his best friend and uncovers corrupt elements of the police department dealing in confiscated drugs.

Convinced he'll graduate with honors because of his thesis paper, a stuffy Harvard student finds his paper being held hostage by a homeless man, who might be the guy to school the young man in life.

When a mysterious entity possesses a young girl, her mother seeks the help of two Catholic priests to save her life.

Private detective and former football player Harry Moseby gets hired on to what seems a standard missing person case - a former Hollywood actress wants Moseby to find and return her daughter. Harry travels to Florida to find her, but he begins to see a connection between the runaway girl, the world of Hollywood stuntmen, and a suspicious mechanic when an unsolved murder comes to light.

After several months of hard times, pianist Eddie Layton is offered the job of bandleader at Olmstead University. His first meeting is discouraging, as the young people are a happy group with very basic musical skills. But Eddie doesn't give up, he wants to motivate his students and his enthusiasm pays off. With the help of French teacher and band sponsor Miss Cooper and billionaire Elmo De Lavallard, who buys new instruments and brightly coloured uniforms, Eddie is proud to lead these musicians who play their hearts out for him.

After federal agent Cleopatra Jones orders the burning of a Turkish poppy field, the notorious drug lord Mommy vows to destroy her.