Animal pals Alex, Marty, Melman, and Gloria are still trying to make it back to New York's Central Park Zoo. They are forced to take a detour to Europe to find the penguins and chimps who broke the bank at a Monte Carlo casino. When French animal-control officer Capitaine Chantel DuBois picks up their scent, Alex and company are forced to hide out in a traveling circus.

After Megamind, a highly intelligent alien supervillain, defeats his long-time nemesis Metro Man, Megamind creates a new hero to fight, but must act to save the city when his "creation" becomes an even worse villain than he was.

A young boy and his dog, who happens to have a genius-level IQ, spring into action when their time-machine is stolen and moments in history begin to be changed.

Skipper, Kowalski, Rico and Private join forces with undercover organization The North Wind to stop the villainous Dr. Octavius Brine from destroying the world as we know it.