Never Give a Sucker an Even Break is a 1941 film about a man who wants to sell a film story to Esoteric Studios. On the way he gets insulted by little boys, beaten up for ogling a woman, and abused by a waitress. W. C. Fields' last starring role in a feature-length film.

Harry is down and out. A woman friend from a temperance union loans him a buck. He goes to a bar and orders a glass of milk to get a free sandwich. After he loses the greenback, the burly saloon keeper confiscates Harry's sandwich and tells him to sweep the floor to pay his tab. In the back room is a boxing ring where the owner stages fights. By happenstance, Harry ends up in the ring. Outside, the temperance union pickets the saloon. Between the beer and the boxing, can Harry stay on his feet and help his crusading friend?

In the midst of some friendly horseplay on their "Flying R" ranch, the Range Busters, Crash Corrigan, Dusty King and Alibi Terhune, are sobered by the arrival of a buckboard bearing their old friend Larry Meadows and his niece Dorrie Willard. Meadows seeks their aid against a gang of outlaws terrorizing his town. Ernie Willard, Dorrie's brother, has been taken in by Tex Laughlin who is using the Willard ranch as an undercover for his real occupation as a member of a gang of outlaws led by Tim Douglas, a supposed friend of the Willards.

A group of frontier businessmen set up a protective organization for the purpose of extorting money from the local ranchers.

A family man becomes innocently involved in an embezzlement.

In turn-of-the-century Cincinnati, vibrant shop girl Ray Smith falls in love with banker Walter Saxel, who is engaged to a socially prominent woman. Inadvertently prevented from running away with Walter, Ray remains single but reunites with him five years later. Despite Walter being married and having a son, Ray becomes his mistress, and over the years suffers social ostracism and long stretches of solitude while waiting for their brief interludes together.

Saved from a lynching party by a pair of young women, an itinerant cowpuncher signs on as a stagecoach guard to protect a shipment of gold.

A recently released prisoner lives alone in his cabin so that his bad temper won't get him back in any more trouble, but his peaceful existence is disrupted when a mysterious woman arrives.

Wily hotel 'hostess' Babe LaVal navigates booming business, cabaret calls and shady deals in Atlantic City. She meets a soup magnate, and begins to feel it might be 'the real thing'.

A detective investigates the mysterious death of a young actress.