High school chums Herman and Shelly navigate the odd transition from much-hyped youthful art prodigies to overlooked adult artists. Ambitions are pitted against lifelong bonds, with the zany mess of the art world acting as an ever-changing backdrop.

Young mattress salesman Brian decides to adopt a baby from China but is distracted when he forms a relationship with quirky, wealthy Harriet whom he meets at his mattress store. As their relationship flourishes, unbeknownst to them, a hitman is trying to kill Brian.