In a last-ditch effort to break through in the crowded and convoluted indie film world, a husband-wife producing team make a film especially designed to win a regional film festival and attract the attention of actor Bill Murray.

Gabriel Higgs has failed to get into Johns Hopkins to study medicine. He's sixth on a list of backup candidates, and must persuade the five people ahead of him to drop out. Gabriel has a family tradition to live up to. Things don't go to plan.

Quiet and unassuming church organist Jenny Moran is depressed with her marriage to working-class Matt and leaves him. Jenny begins an affair with the manipulative and charming Dr. Stephen Carrow, who is also deacon of her church and a married man. Someone kills Carrow's wife after she learns of the affair between Jenny and her husband. The murderer is caught and confesses, but that confession leads to new lies which tear apart Jenny Moran's life.