A drunken, self-destructive woman called Betty wanders into a Parisian bar where she meets middle-aged alcoholic Laure. Laure decides to take care of Betty. Recovering in a hotel room, Betty begins to recount to Laure the story of her bourgeois life and her unhappy and unfaithful marriage.

Magistrate Jeanne Charmant-Killman doggedly investigates CEO Michel Humeau, who is accused of participating in massive corporate malfeasance. As her investigation leads her into the upper echelons of government, Jeanne becomes intoxicated by the power she is amassing.

Betty and Victor, a rather ill-matched couple, tour unobtrusively around France in their motor-home, earning their living as petty con artists, until one day they find themselves involved in an international money scam which takes them on a globe-trotting adventure.

When a teenager suddenly disappears without a trace, the case is assigned to an alcoholic police officer who maintains a complicated relationship with his own troubled teenage son, suspected of drug trafficking.

Olivier Assayas, Gus Van Sant, Wes Craven and Alfonso Cuaron are among the 20 distinguished directors who contribute to this collection of 18 stories, each exploring a different aspect of Parisian life. The colourful characters in this drama include a pair of mimes, a husband trying to choose between his wife and his lover, and a married man who turns to a prostitute for advice.