The PFL 2 mixed martial arts event for the 2018 season of the Professional Fighters League was held on June 21, 2018, at the Chicago Theatre in Chicago, Illinois. It was the second regular season event of 2018 and included only fights in the lightweight and light heavyweight divisions.

The PFL 10 mixed martial arts event for the 2019 season of the Professional Fighters League, the 2019 PFL Championship, was held on December 31, 2019, at the Hulu Theater at Madison Square Garden in New York City, New York.

The PFL 4 mixed martial arts event for the 2021 season of the Professional Fighters League was held on June 10, 2021. This was the fourth regular season event of the tournament and included fights in the Featherweight and Lightweight divisions. Boxing champion and Olympic gold medalist Claressa Shields made her MMA debut in the main event against Brittney Elkin.

The PFL 4 mixed martial arts event for the 2022 season of the Professional Fighters League was held on June 17, 2022 at the Overtime Elite Arena in Atlanta, Georgia. This marked the fourth regular season event of the tournament and included fights in the Lightweight and Light Heavyweight divisions.

The PFL 1 mixed martial arts event for the 2021 season of the Professional Fighters League was held on April 23, 2021. This was the first regular season event of the tournament and included fights in the Featherweight and Lightweight divisions. The event was headlined by a lightweight clash between the former UFC and WEC Lightweight champion Anthony Pettis and the UFC veteran Clay Collard.

The PFL 10 mixed martial arts event for the 2022 season of the Professional Fighters League will be held on November 25, 2022, at the Hulu Theater in New York City, New York, United States. This will be the finale of the playoffs for all divisions, with the winners getting $1 million cash prize. The event also will also mark the organization's first pay-per-view card, being available on ESPN+ PPV.

The PFL 11 mixed martial arts event for the 2018 season of the Professional Fighters League was held on December 31, 2018, at the Hulu Theatre at Madison Square garden in New York City, New York, Illinois.