While bouldering with her friend Jade, gym climber Rose falls for Bret, an experienced outdoorsman. She talks him into taking her - against his better judgment - on a famous, advanced rock-climbing route called "Killer Pillar." Disaster strikes when Bret falls and suffers a serious head injury and torn shoulder, leaving it up to Rose to save them both.

When inept, self-proclaimed survival experts Kaduche and Wynn discover the world's impending destruction, they pull their act off YouTube and enter Epic Mode to save the Earth. Teaming up with their nemesis, the girl of their dreams, and an eccentric visionary known as the Oracle, the group sets out to battle domestic terrorists, disenfranchised Russian communists and brain-eating zombies.