Sisters and the Shrink is based on the real-life story of six ordinary women who face regular everyday problems at both home and work and seek the assistance of a shrink to help channel their thoughts and find a solution to their problems. The hired shrink attempts to listen their drama-filled lives and provide ways for the "sisters" to repair broken relationships, friendships, and family ties. The women seem to always blame others but fail to realize they are part of the problem

Fed up with being single on holidays, two strangers agree to be each other's platonic plus-ones all year long, only to catch real feelings along the way.