In a futuristic Tokyo where police have been privatized and bitter self-mutilation is so casual that advertising is often specially geared to the 'cutter' demographic, Ruka is on a mission to avenge her father's assassination. Ruka is a cop from a squad whose goal is to destroy homicidal mutant humans known as 'engineers', that possess the ability to transform any injury to a weapon in and of itself.

Yuichiro wants to be an film director but his widowed mother wants him to become a doctor. As radiation leaks permeate the city, he tries to clear his debts by signing up for a dangerous medical experiment...

Ogura Akane is twenty six years old and wants to become a designer. However, things go awry when in a double whammy she loses her job and finds her boyfriend cheating on her.