A new infection that simply makes people feel happy is treated as a threat by the authorities while its "victims" work to spread it to others.

Not only did Mary Tyler Moore “turn the world on with her smile,” as her show’s theme song declared, she also influenced a generation of women to become more independent and to pursue successful and fulfilling careers. Moore’s own 50-plus-year career has spanned award-winning films and Broadway shows, as well as two beloved television series that broke ground and continue to entertain viewers. ​ This one-hour special includes highlights from a recent interview with Mary Tyler Moore, tributes from her co-stars and clips from iconic moments throughout her career. The program looks at her breakthrough role on The Dick Van Dyke Show, her iconic turn as TV's first independent career woman on The Mary Tyler Moore Show and her Academy Award-nominated work on Ordinary People.

A hapless talent manager named Danny Rose, by helping a client, gets dragged into a love triangle involving the mob. His story is told in flashback, an anecdote shared amongst a group of comedians over lunch at New York's Carnegie Deli. Rose's one-man talent agency represents countless incompetent entertainers, including a one-legged tap dancer, and one slightly talented one: washed-up lounge singer Lou Canova, whose career is on the rebound.