Two Dollar Bill is shown from the perspective of teenage roommates Greta and Harper. Their friendship is tested when Greta’s friend Frankie appears unexpectedly on Halloween. An examination of modern girl culture, this is a story of young women leaving home a little early.

Zu, a free spirit estranged from her family, suddenly finds herself the sole guardian of her half-sister, Music, a teenager on the autism spectrum whose whole world order has been beautifully crafted by her late grandmother. The film soon challenges whether it is Zu or Music who has a better view of the world, and that love, trust, and being able to be there for each other is everything.