Dr. Hattori and her husband watch footage of brain surgery experiments with Manchurian, Russian and Japanese guinea pigs that had been found in the basement of a wrecked hospital. Out of the blue, there is a white light and when they look back, they see they children Ota Miyuki and Kaori staring at the light. Years later, Miyuki vanishes from the Tama Medical University Hospital and her sister Kaori, Miyuki's boyfriend Motojima and detective Hirasawa are seeking her. However, Miyuki and the teenagers Kazochi, Takumi, Hattori and Rieko have been submitted to a nightmarish experiment by Dr. Hattori and her team with tragic results.

Up-and-coming lawyer Sayoko Kirishima takes on the defense of Onodera, the suspect in a rape case involving a high school girl. Onodera, harboring an abnormal love for Sayoko, confines her. As she endures endless abuse, Sayoko gradually loses her sanity. Before long, she becomes addicted to the perverse pleasures and lust of the situation...