In 1923 the scientist Von Dracula invented Vampisol, a drink that allowed vampires to live in the sun. La Capa Nostra and the European Vampire Group confront each other in Havana to control the Vampisol, but Pepe, Von Dracula's nephew, sang the Vampisol formula for free on Radio Vampiro Internacional. Now Pepe must face the Nazi vampires, who use the most powerful Vampisol: El Vampiyaba.

Elpidio Valdés returns to the Cuban countryside to fight against the Spaniards. But they have a much more dangerous enemy: the Americans, who want to take over the island at any cost. Elpidio Valdés and his comrades-in-arms will try to prevent them from achieving their goal, with machetes in hand and bullets flying. It was conceived as a series for Spanish television and later shown as a feature film under the name Más se perdió en Cuba (More Was Lost in Cuba) in Spain and Elpidio Valdés contra el águila y el león (Elpidio Valdés Against the Eagle and the Lion) in Cuba.

Professor Von Dracula, a vampire scientist, leaves Transylvania for Cuba, where he invents "Vampisol," a potion that allows vampires to survive in sunlight. When the professor announces his intention to donate the formula free-of-charge to vampires all over the world, the Vampire Mafia from Chicago and the European Group of Vampires from Düsseldorf try to muscle in and steal the formula. The action escalates crazily as an assortment of bad guys, police, vampires and other monsters, and our hero and his girlfriend are all caught up in the chase.