Yiorgos is released from prison after 14 years of incarceration for a murder he committed in his small Greek village. He spends his first night out in a cheap downtown hotel in Athens. There he meets Strella, a young trans sex worker. They spend the night together and soon they fall in love.

Four sets of passengers and their romantic antics make the night shift of a rideshare driver one to remember.

The protagonist is "Mrs. Epitheoresis" herself, who returns to the stage to travel her great-grandson back in time, to her most important moments. On the stage parade the legendary protagonists, the inimitable lines, the great voices, the immortal songs, the glittering theaters of the golden age of the epitheoresis. And up close, current events, political and social changes, urbanization, the fate of Greece - always with humor and a satirical mood. "Kyria Epitheoresis" takes the viewer by the hand and guides them through the bars and historical theaters of Athens from the 1930s to the beginning of the dictatorship in 1967.