As part of the conquest of Mexico by the Spaniards, Rodrigo, a Spanish shipwreck falls in love with Tizcuitl, the young and beautiful Aztec daughter of Nezuhual, king of Tlacopan, powerful under the emperor Moctezuma.

End of the 20's. Alfonso a young writer brought up in France, arrives to an adventurous mining town (Uyuni) in the midst of the Bolivian high plateau. Here he meets the beautiful Claudina a sensual, strong willed chola, la "Misqui simi" ("The one with the sweet lips"). Uyuni radiates a strange magnetism, it is charged with a collective euphoria produced by the bewitching mineral. The lives of the characters enter a whirl of passion, ambition and frustration.

Lourdes is almost 24, works at a casting agency and takes care of her handicapped father, since her mother abandoned them years ago without explanation. Strange for her age and despite the advice of her best friend Victoria, Lourdes has never had a boyfriend or a kiss, just an internet flirt. One day, her mother returns home, reopening old wounds

Sometimes you can live your whole life in a few days... A high school graduation trip in which love, friendship, desire, illusion, innocence and the forbidden are all part of the adventure. Charm and disillusionment shine through teenage friendships as the characters try to understand what is happening to them and what they should do with their future.