Margie, a medical technician whose dream of becoming a doctor has never come into fruition, and Mike, an artist who struggles to get by in his day-to-day life, are two estranged lovers who have fallen in love in each other only to find their relationship crumbling to pieces. Five years later, they meet again and they ask themselves if they could be together again, if they have learned from the mistakes they made in the past, if it is too late to start all over again.

Three women with totally different lives accidentally get their souls switched as they struggle with the comedic misadventures of their new worlds, they realize that their own lives and families are worth loving and living for. Jolene, a famous person who always has fans in public, Mylene - an overprotected lady who always gets pleasure and love and Karlene - a rich famous social media influencer all switch bodies but their lives did not just change, but their souls switched that leaves them with no choice but to stick together to live the peculiar lives of each other. Karlene then has to convince a group of investors to invest in her near-bankrupt hotel, but no one believes her because she is trapped in Mylene’s body. In the process of all of their imaginative scenarios, they drew closer to each other into becoming the soul sisters they are destined to be.

The story of the Mamasapano clash where 44 Special Action Force officers of the Philippine National Police (PNP) died on their mission from the point of view of then-PNP Deputy Chief of Operations Major General Benjamin Magalong as he was heading the investigation.