Andy Stitzer has a pleasant life with a nice apartment and a job stamping invoices at an electronics store. But at age 40, there's one thing Andy hasn't done, and it's really bothering his sex-obsessed male co-workers: Andy is still a virgin. Determined to help Andy get laid, the guys make it their mission to de-virginize him. But it all seems hopeless until Andy meets small business owner Trish, a single mom.

Junk Food consists of four intertwining stories. The first and fourth sections show the morning routine of an blind, old Japanese woman, waking up, buying bread and milk, praying at the family altar; however, it is the second segment where the true story begins.