Bad Luck Joe is the story of everyday people who get caught up in a power play between two widows, Madam Francesca and Aunty Beatrice who are fighting over their husband properties. A fight that takes the characters on an interesting ride as they try to find a missing body. There is Joe, (played by Chris Attoh) a broke troubled man who is struggling to change his ways and better his fortunes after finding love in Abena (played by Adomaa). There is Zuri (played by Sika Osei) a daring and energetic young lady who is haunted by an unfortunate event in her past, who is bent on making things right between her and her father. And then there's Elizabeth, (played by Kande Talata Awudu) who is a caring wife committed to her marriage regardless of the tedious task of having to deal with a clingy and needy husband who is confined to a wheelchair even as she compelled to enforce the plans of her aunt, Madam Francesca who is seems too sophisticated to want to get her own hands dirty.

Three actresses must each resolve their conflicting romances to prevent their personal drama from going public and wrecking their careers.