The madcap life of eccentric Mame Dennis and her bohemian, intellectual arty clique is disrupted when her deceased brother's 10-year-old son Patrick is entrusted to her care. Rather than bow to convention, Mame introduces the boy to her free-wheeling lifestyle, instilling in him her favorite credo, "Life is a banquet, and most poor sons of bitches are starving to death."

Maggie Cole is a research scientist who, after the sudden death of her husband, takes a position as an on-call doctor in an inner-city clinic. There, she must fight a battle on two fronts: against the medical conditions endangering her patients and against sexism toward a female doctor.