Derrick, a corporate lawyer with a large trust fund, and Zane, a criminal, live in opposite social spheres. Although they never meet, their lives are more connected than either one of them could ever imagine.

Charlie Corrado is pushing forty and still lives with his grandparents, Martin and Marion Corrado. Although he feels safe in the environment they have created for him, he spends his days and nights longing for something more out of life.

Poker addict Mike McDermott knows the game inside out, but loses his money one night in a game to Russian-American gangster Teddy KGB. Promising his partner Jo he'll give up, he meets up with best friend Lester 'Worm' Murphy, just out of prison and owing lots of money to the wrong kind of people. McDermott becomes his co-guarantor and now there's only one way to raise the money, the pair have to get back into the game.

In the year 2035, convict James Cole reluctantly volunteers to be sent back in time to discover the origin of a deadly virus that wiped out nearly all of the earth's population and forced the survivors into underground communities. But when Cole is mistakenly sent to 1990 instead of 1996, he's arrested and locked up in a mental hospital. There he meets psychiatrist Dr. Kathryn Railly and the son of a famous virus expert who may hold the key to the Army of the 12 Monkeys; thought to be responsible for unleashing the killer disease.

Marco is a model student and leader of a group of guys who are adrift. He hides a terrible secret: he's a champion in clandestine fights managed by a cruel trafficker.