Jessie deals with a bad breakup, by purchasing a sheet of acid to share with his friends back home in Missouri. He hopes this will erase the bad memory of his college girlfriend, delivering the heartbreaking news to him, during sex. Departing New Orleans, Jessie detours onto Route 61, seeking a change of routine from the monotony of the Interstate. Unexpectedly, his engine fails at a forgotten trailer park in Cleveland, Mississippi. Fearful he's about to be harmed by bikers, Jessie exchanges hits of L.S.D. for safe passage home. During the ebb and flow of the day, Jessie experiences the extraordinary in the pedestrian, whilst resurrecting the lives of many. Inspired by a true misadventure.

On a hot summer night in New Orleans, Angel and Dee prowl the French Quarter looking for prey. They, however, don't know they're being hunted themselves by a man bent on revenge.

Former frat brothers return to Spring Break, trying to recapture their former glory days, while capturing video for their hastily conceived smart phone app "Bikini Girls Behaving Badly".

A reporter stumbles upon the journal of a murderer with plans to butcher specific girls, and he begins to investigates on his own, and finding that every trail leads to a 9-year-old orphan living in a group home.

Nicky, an accomplished con artist, gets romantically involved with his disciple Jess but later ends their relationship. Years later, she returns as a femme fatale to spoil his plans.

A pool boy and a gardener turn an empty mansion into a home for women who belong to the world's oldest profession.