Mario "Cantinflas" Moreno is a hired hand, Pepe, employed on a ranch. A boozing Hollywood director buys a white stallion that belongs to Pepe's boss. Pepe, determined to get the horse back (as he considers it his family), decides to take off to Hollywood. There he meets film stars including Jimmy Durante, Frank Sinatra, Zsa Zsa Gabór, Bing Crosby, Maurice Chevalier and Jack Lemmon in drag as Daphne from Some Like It Hot. He is also surprised by things that were new in America at the time, such as automatic swinging doors. When he finally reaches the man who bought the horse, he is led to believe there is no hope of getting it back. However, the last scene shows both him and the stallion back at the ranch with several foals.

The ghost of "patient zero", who allegedly first brought AIDS to North America - materialises and tries to contact old friends. Meanwhile, the Victorian explorer Sir Richard Burton, who drank from the Fountain of Youth and now works as Chief Taxidermist at the Toronto Natural history Museum, is trying to organise an exhibition about the disease for the museum's "Hall of Contagion".

This film powerfully documents New York City's gay community's response to the AIDS crisis as they are forced to organize themselves after the government's failure to stem the epidemic. Activists who are interviewed include playwrite Larry Kramer, People With AIDS Coalition co-founder Michael Callen (who died of AIDS in 1994), New York filmmaker and journalist Phil Zwickler, as well as representatives from ACT-UP, Queer Nation and the Gay Men's Health Crisis.

Sex Positive explores the life of Richard Berkowitz, a revolutionary gay S&M hustler turned AIDS activist in the 1980s, whose incomparable contribution to the invention of safe sex has never been aptly credited. Mr. Berkowitz emerged from the epicenter of the epidemic demanding a solution to the problem before the outside world would take heed. Now destitute and alone, Mr. Berkowitz tells his story to a world who never wanted to listen.

Two competing lawyers join forces to sue a prestigious law firm for AIDS discrimination. As their unlikely friendship develops, their courage overcomes the prejudice and corruption of their powerful adversaries.