Three close knit 12-year-olds - introverted Jacob, precocious Malee and vulnerable Leonard - start down the path of self-discovery and begin to distinguish their own voices from those of their parents.

Stuart, an adorable white mouse, still lives happily with his adoptive family, the Littles, on the east side of Manhattan's Central Park. More crazy mouse adventures are in store as Stuart, his human brother, George, and their mischievous cat, Snowbell, set out to rescue a friend.