Derek Rillix is a Nerd Hunter, a special officer assigned to hunt down and delete anyone engaged in illegal "NERD" activities. Rillix knows that the underground nerd movement, led by MasterGeek, are planning a massive comic book convention. Rillix is bent on stopping this, but something is gnawing away deep inside him, a deep secret that even he cannot face.

A young man awakens from a four-year coma to hear that his once virginal high-school sweetheart has since become a centerfold in one of the world's most famous men's magazines. He and his sex-crazed best friend decide to take a cross-country road trip in order to crash a party at the magazine's legendary mansion headquarters and win back the girl.