Is all scientific research for the good of mankind? An amazing June night. A peaceful mansion surrounded by forest, where a happy family prepare for a dinner. Human guinea pigs, modified to become a real weapon escape an illegal clinic appear in the same forest. A family who has bonded instinctively together in order to protect each other from harm, or genetically altered, callous humans. Who will survive the onslaught?

Kuzey runs a hotel called Karayel in Eski Foça with his friend Sami. In 1998, a young and beautiful woman named Şafak comes to Eski Foça to conduct research on Greek villages and stays at the Karayel Hotel. Şafak falls in love with Kuzey, but Kuzey only cares for her. Şafak leaves Kuzey five times, but always returns… On her final departure, she disappears while driving away. All searches prove fruitless; Şafak is missing. Kuzey continues searching for Şafak for five years with his friend, the fisherman Yunus… In 2003, Çiğdem arrives at the hotel. Çiğdem, who is Kuzey’s brother’s assistant, takes on the hotel’s debts and saves it from bankruptcy. During this time, Çiğdem also develops feelings for Kuzey. This only serves to remind Kuzey of Şafak once again. After Fisherman Yunus tells him that he found the remains of Şafak’s car underwater, Kuzey leaves the hotel. He goes to the same place to meet Şafak…

Selma and Sinan are a couple who now find it difficult to endure each other. At the end of high school, rumors start circulating about their son Umut, who is gay. While Selma and Sinan are trying to cope with their tiring marriage, Umut suddenly disappears.