A young Honduran immigrant and a mother, whose son wants to confine her in a residence, decide to go to Huelva. During the trip they are forced to run away from several pursuers, attack a service station, face the Guardia Civil and meet a false Englishman who changes their lives. Nevertheless, their goal is to arrive to a nightclub called Mami Blue, venue of an unexpected end.

Ani and Niko are 16 and dating, but their lives couldn't be more different. She is the daughter of a taxi driver and a housewife and has always been happy and contented. Niko delivers pizzas, his mother is an alcoholic since his father abandoned them and his brother is a gang member and drug addict. The world of the young couple is altered by the increasingly frequent appearance of burned cars on weekends. Organized neighborhood patrols in the working class neighborhood will eventually trigger a tragedy that will affect them both.

In September 2003, Alejandra López de Lemos, eldest daughter of a professor of art history at the University of Seville, disappears without a trace. All suspicions fall on her ex-husband, but the police find no evidence against him. Several months go by and the media attention wanes. Then a journalism student decides to do her final thesis on the case...

A gay gym teacher wants to be a father and when his boyfriend's sister, a former addict, comes back on the scene there is now a possible solution.