In the Mexican town of Santa Clara, Salma, a 16 year-old orphan who never got to meet her biological parents, has spent most of her life searching for clues of their identities and whereabouts, that is until she discovers a special book that is filled with stories of the town's past and the history of it's people.

Despite his family’s baffling generations-old ban on music, Miguel dreams of becoming an accomplished musician like his idol, Ernesto de la Cruz. Desperate to prove his talent, Miguel finds himself in the stunning and colorful Land of the Dead following a mysterious chain of events. Along the way, he meets charming trickster Hector, and together, they set off on an extraordinary journey to unlock the real story behind Miguel's family history.