A "New Media" news coverage team (W.H.I.S.T.L.E.) is stranded near a beleaguered brothel in the middle of nowhere; recovered footage will reveal what happens when they encounter a group of women with a terrifying secret.

After a car crash sends repressed cartoonist Stu into a coma, he and the mischievous Monkeybone, his hilarious alter-ego, wake up in a wacked-out waystation for lost souls. When Monkeybone takes over Stu's body and escapes to wreak havoc on the real world, Stu has to find a way to stop him before his sister pulls the plug on reality forever!