One last job and Love is out of the erotic escort business. Unfortunately, that final job is for a trio of escaped mental patients who are looking to change the world. One victim at a time.

Pelle's brother has been missing for a month when a mysterious phone call tells him to watch the top rated reality show, Public Enemy Number One. It's a nasty piece of work where contestants tape their murders and battle it out to be the top killer for that year. When Pelle sees the episode in question he realizes the brutal chainsaw murder was filmed in his brother's apartment. Going there, he searches to find out if the footage is real. Little does he know that he's stepped into ground zero for a pitched battle of famous past Public Enemies and those who would take their place.

Returning to the same medical school where they were test subjects years before, two twisted serial killers use brutal sex acts to kill off a group of med students.