It's time for the annual Dooley family reunion and Dooley matriarch Meemaw's 100th birthday celebration. But teenaged Billy is welcomingly distracted from wacky relatives and the ultra-competitive family games by a mysterious runaway named Samantha. In the meantime, Meemaw, does some running away herself.

The film centers around two hijackers that take over a plane. The problem is: The airplane is not carrying a billionaire as planned, but otherwise is carrying a group of smart children.

Nan, seventeen, wakes up alone in a motel room and wonders how she got there. The events of the preceding night come back to her on the subway ride home: a vicious argument between her parents, a one night stand and finally a betrayal.