René is determined to make changes in his life and learn to say no, but his neighbor manages to persuade him to look after her sick sister-in-law.

When Rodrigo meets María Luisa, he realizes they have very different personalities. As time moves forward, an unfortunate event makes them fall in love with each other.

After a breakup, Sofía moves to the capital city, where she meets Leonardo, but when they try to have sex for the first time, he gets seriously ill.