Special female detective Hanyu Asuka, codenamed 348 (Sashiba), receives a secret mission from the police commissioner to solve the blackmail case involving a genius Famicom designer. As Asuka continues her investigation, she discovers that Hayami, a gangster, is the culprit. However, after a gunfight, Hayami escapes, and a few days later, policewomen are killed one after another, as if in retaliation for Asuka...

A woman who has given up on truly loving others and seeking human warmth. Due to a sudden accident in which such a woman is kidnapped, she begins to love a man for the first time. But the man also had the same eyes as me. He too could only lead a rough life, never loving others. The woman begins to love the man seriously, as if her own life is at stake, and the man gradually begins to accept the woman's heart.

Melvin Junko was a nerdy weakling until he fell into a vat of toxic waste, turning him into the first ever superhuman creature from New Jersey. This time, he takes on Tokyo.

Nami is a nurse and the unwilling object of her patients' lust. When she is hit by a car whilst fleeing from the home of her unfaithful boyfriend, the driver of the car takes her as a sexual prisoner.

Stripped of purpose and poisoned by corporate evil, the Toxic Avenger is turned against Tromaville. Now, in this definitive cut of Parts II and III, he must confront the monster he's become before his town and soul are lost forever.