Lovable Sulley and his wisecracking sidekick Mike Wazowski are the top scare team at Monsters, Inc., the scream-processing factory in Monstropolis. When a little girl named Boo wanders into their world, it's the monsters who are scared silly, and it's up to Sulley and Mike to keep her out of sight and get her back home.

Led by Woody, Andy's toys live happily in his room until Andy's birthday brings Buzz Lightyear onto the scene. Afraid of losing his place in Andy's heart, Woody plots against Buzz. But when circumstances separate Buzz and Woody from their owner, the duo eventually learns to put aside their differences.