After years of suffering from post-traumatic stress disorder, six US veterans of the wars in Iraq and Afghanistan travel to Peru on a quest for healing. With the help and guidance of three brothers who are traditional healers, they take ayahuasca and other plant medicines during a 10-day retreat in the Amazon rainforest.

How do we heal our deepest wounds? Two combat veterans, suffering from severe trauma, abandon pharmaceuticals in order to seek healing through psychedelic medicines. Recent scientific research has shown that these substances can help people to recover from post-traumatic stress disorder (PTSD). Beyond the personal stories, From Shock to Awe raises fundamental questions about war, the pharmaceutical industry, and the US legal system.