A trio of interweaved transgressive tales, telling a bizarre stories of suburban patricide and a miraculous flight from justice, a mad sex experiment which unleashes a disfiguring plague, and the obsessive sexual relationship between two prison inmates.

In this loose adaptation of Shakespeare's "Henry IV," Mike Waters is a hustler afflicted with narcolepsy. Scott Favor is the rebellious son of a mayor. Together, the two travel from Portland, Oregon to Idaho and finally to the coast of Italy in a quest to find Mike's estranged mother. Along the way they turn tricks for money and drugs, eventually attracting the attention of a wealthy benefactor and sexual deviant.

Final 24 recreates River Phoenix's last day to tell the tragic tale of a young man whose short life was dominated by the constant pressure to perform.