James Bishop is a young psychology resident, excited about his new job at St. Andrews Mental Hospital and the chance to help severely ill patients. The excitement changes to puzzlement, concern and finally terror as some of those patients mysteriously die and James' efforts to find the cause results in increasingly strange behavior from the St. Andrews staff. Things begin to clarify when James finally encounters the Harvester...

When Julius (Marty Sader) loses his girlfriend, his job and the life of his pseudo father, Jack, his itch for a "quick fix" suffocates his ambitions and takes him on a trip through the disturbing addiction of crystal meth. Julius confides in Erica (Laura Keys), who lures him into her erratic lifestyle, and their crazy romance brings him terrifying hallucinations and isolation as he learns that hedonism will not eliminate his pain.

At the end of their college years, Miller finds that he and his college buddies are growing apart as they choose different paths into the future. They are regulars at Murphy's, a popular watering hole of choice where Miller and Jim meet with their buddies and are free to vent, decompress, and talk about life.